Which of the following substances is classified as a Schedule III controlled substance?

Tylenol 3, which contains a combination of acetaminophen and codeine, is classified as a Schedule III controlled substance. The inclusion in this category signifies that it has a potential for abuse that is less than substances listed in Schedules I and II, but more than those classified as Schedule IV and V. Schedule III substances can be prescribed by healthcare professionals and may be refilled up to five times within six months.

In contrast, other substances listed in the question fall into different schedules. Cocaine is classified as a Schedule II substance due to its high potential for abuse. Methadone is also classified as Schedule II because it is used as a powerful pain reliever and has a significant addictive potential. Ketamine, commonly used for anesthesia and other medical purposes, falls under Schedule III in some contexts as well, but depending on state regulations, it can have stricter controls in practice. Thus, Tylenol 3 accurately fits the criteria for Schedule III classification, emphasizing the importance of understanding the specific substances that are listed in this category.